Hamas militants have fired rockets towards the Dimona nuclear reactor facility, an Israeli military spokesman has confirmed.
The official said three rockets were detected, however there have not been any reports of damage or injuries.
The strike attempt comes after the Israeli military has said it has shot down rockets fired by Palestinian militants at other areas, as Israel's major air offensive over the Gaza Strip approaches its third day.
A spokesperson for the Israeli Defence Forces (IDF) said at least eight rockets sent from Gaza were intercepted over Tel Aviv, Ashdod and Ashkelon on Wednesday.
A wounded Palestinian is stretchered into hospital
Israel said a rocket hit the city of Zichron Yaakov on Wednesday afternoon, which is some 75 miles from Gaza, representing the longest-range rocket strike by Hamas on the state to date.
The IDF claims at least 48 missiles, sent by the Islamist militant group Hamas, which controls Gaza, have "struck Israel" since midnight.
Other locations targeted included Beersheva and Sderot in the south, Rishon Lezion, and Hadera in the north - 60 miles from Gaza.
In total, more than 300 rockets have been fired at Israel since the military launched Operation Protective Edge began on Monday night.
To date no fatalities have been reported in Israel.
The fatalities come after at least 49 people, including children, have been killed in the biggest Israeli assault on Gaza in nearly two years.
Officials in Gaza say that more than 300 people have also been injured since Monday, but that number is likely to climb as Israel attempts to "dismantles" Hamas.
The Israeli military said a total of 550 Hamas targets have been hit since the operation began, with 130 targets hit on Wednesday.
A house in Gaza destroyed by an Israeli attack
They included 60 suspected rocket launch sites on the Gaza Strip from Beit Hanoun in the north, to Rafah near the Egyptian boarder.
Israeli Prime Minister Benjamin Netanyahu's office has quoted him as saying he plans to "intensify the attacks on Hamas and the terrorist organisations in Gaza" even further.
At a crisis meeting in the West Bank city of Ramallah, Palestinian President Mahmoud Abbas accused Israel of committing atrocities in Gaza.
Mr Abbas said: "It's genocide - the killing of entire families is genocide by Israel against our Palestinian people."
The IDF says Hamas is firing from civilian areas. Pic: IDF/Twitter
The exchange of fire marks the heaviest fighting between Israel and Hamas since an eight-day battle in November 2012.
Israeli government spokesman Mark Regev told Sky News Israel's actions are "defensive" and designed to eliminate rocket fire.
The Israeli cabinet has warned it may also send in ground troops and has authorised the call-up of as many as 40,000 reservists.
On Tuesday, wedding guests in Holon, central Israel, were forced to run for shelter after sirens alerted them to incoming missiles.
Israeli tanks at the southern border with the Gaza Strip
Video footage shows Israel's 'Iron Dome' defence system intercept an incoming rocket.
The IDF said 80 rockets have been intercepted and neutralised by the defensive system.
It also posted an image on Twitter which it said shows rockets being sent from civilian areas in Gaza.
Israel and Hamas had, until recently, been observing a truce that ended the 2012 hostilities.
Israel has also prepared for a ground invasion of Gaza
Tensions increased last month after three Israeli teenagers were kidnapped and killed in the West Bank.
Israel blamed Hamas and launched a crackdown on the group's members and arrested hundreds of people.
The situation deteriorated further last week when a Palestinian teenager in Jerusalem was abducted and burned to death in what was viewed as a revenge attack.
According to news agency Reuters, a US official involved in the investigation into the deaths of the three Israeli youths has revealed they were shot at least 10 times with a silenced gun, indicating premeditated murder.