A lorry crash on the M25 is likely to cause rush hour chaos after the Highways Agency announced part of the motorway would be closed for most of the day.
Police said there were severe delays on the northern part of the M25 after it was shut in both directions between junction 23 at South Mimms in Hertfordshire and junction 25 at the junction with the A10 north of Enfield in north London.
Clockwise traffic caught immediately behind the crash has now been released, according to the Highways Agency.
One person is in critical condition after the crash Motorists have been asked to consider alternative routes.
Police have arrested the lorry driver on suspicion of causing serious injury by dangerous driving. He remains in custody at a police station in north London.
Many drivers have taken to Twitter to express their frustration at the delays.
"Thanks M25 - Nothing like spending 6 hours in traffic to round off your week," wrote David Hobson.
Others were more upbeat about the incident.
Aerial footage of the crash scene "M25 is shut in both directions this is the time where all the little rat runs you learn working in a van pay off," wrote Daniel Cooper.
Four people were hurt when the lorry overturned around 9:30am, forcing police to close the carriageway while emergency services attended the scene.
One man was taken to a hospital in Cambridgeshire by the Hertfordshire Ambulance Service, where he remains in a critical condition.
A second man was taken to a central London hospital by the London Air Ambulance in a serious condition.
The closed off section of the motorway A third man is being treated at a central London hospital for a leg injury. The fourth man received treatment at the scene for minor injuries.
It is the second time in three days the M25 has partially closed.
On Tuesday, the M25 had to be closed between J23 and J25 after the driver of a lorry died when the vehicle overturned and caught fire near J25.
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