A car bomb and two other explosives have struck the interior ministry in Damascus, causing some deaths, according Syrian state TV.
The blasts reportedly occurred at the main entrance to the building situated in the southwest district of Kafar Souseh - a battleground for rebels and forces loyal to Syrian President Bashar al Assad.
"Three terrorist explosions caused damage to the interior ministry's main facade, and there are reports of casualties," the broadcaster said.
"One of the terrorist explosions that targeted the interior ministry's main entrance was a car bomb," it added.
No details of the number of dead and wounded, the size of the bombs or the damage caused were disclosed.
The pro-government TV station Al-Ikhbariya aired footage of concrete rubble, blood on the floor and two-metre-wide hole in the road.
Damascus on Wednesday night - moments after the explosion A resident who heard the blast said she head sirens and shouting after a "huge explosion".
The adjacent building housing the Egyptian embassy was also hit, Egypt's official MENA news agency reported.
Sky's foreign affairs editor Tim Marshall, who is in Damascus, said: "We think we heard it. It was an explosion much, much louder than most of the ones we hear. You could actually feel the shockwave
"There was a huge plume of white smoke near the government buildings.
"We hear the artillery firing every few minutes - it is a certain sort of boom. This was a much, much deeper sound and a much louder sound.
"I think that was the bomb that went off. The most likely thing would be a car bomb.
"A series of ambulances came racing up the street behind us ... and a whole convoy of government cars."
The blasts follow four car bombings in the city on Wednesday. There were two in the eastern district of Jaramana, one of which killed a civilian, and two others later near a court building.
It comes as the US joined several other western and Arab nations in formally recognising Syria's opposition coalition as the legitimate representative of the nation's people.
The scene of a car bombing in Jaramana just over two-weeks-ago France, which with the UK has already formally recognised the Syrian National Coalition as the government-in-waiting, said more than 100 nations had now followed suit.
The apparent breakthrough came after British Foreign Secretary William Hague told the Friends of Syria meeting in Morocco that he was "deeply disappointed by the failure of the international community" to throw its weight behind it.
"We do not know how long the conflict in Syria will last," he said.
"Helping the National Coalition to win the confidence of the Syrian people, planning for a peaceful future for the country and protecting the victims of the conflict on whom that future will rest, is surely the right way to seek to end the conflict and stop the appalling loss of life," he added.
The conflict, which has claimed the lives of of least 40,000 people since March 2011, has been centred in and around the capital in recent months - and it is not the first time government and national security buildings have been targeted.
On July 18, the president's brother-in-law Assef Shawket, defence chief Daoud Rajha, and general Hassan Turkmani, a former defence minister and senior military official, were all killed in a bomb attack at a meeting of senior security and government figures in Damascus.
And more recently, more than 50 people were killed after two car bombs went off in Jaramana on November 28.
An al Qaida linked group, al Nusra Front, has claimed many deadly blasts inside Syria.
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