A two-year-old girl who died after suffering a cardiac arrest may have ingested methadone, according to police.
Sophie Jones was taken to Blackpool Victoria Hospital from a house in Jameson Street, Blackpool, Lancashire, on Tuesday night but later died.
A post-mortem examination has failed to ascertain the cause of death and toxicology tests have now been ordered.
Officers believe Sophie may have ingested methadone, which was then removed from the house either shortly before or just after paramedics arrived.
Sophie Jones suffered a cardiac arrest in a house in BlackpoolThey are also investigating whether the little girl had ingested alcohol.
Detective Superintendent Paul Withers, of Lancashire Police, said: "I will not leave a stone unturned to identify and ascertain how Sophie died.
"We're all very very determined to find some justice for Sophie and to try and identify why this beautiful two-year-old child, little girl, is now dead.
Det Supt Paul Withers says the methadone may have been removed"As a result of our enquiries I believe that a substance was removed from the address on Jameson Street either shortly before paramedics arrived or after, and I believe that substance to be methadone.
"Methadone is green in colour and in this instance may not necessarily be in a clearly identified medicine bottle."
Detectives have been granted more time to question a 29-year-old woman and a 41-year-old man. They are being held on suspicion of manslaughter and attempting the pervert the course of justice.
A 65-year-old woman and a 60-year-old man were also arrested, but later released.
:: Anyone with information should contact police on 101 or Crimestoppers on 0800 555 111.
:: Watch Sky News live on television, on Sky channel 501, Virgin Media channel 602, Freeview channel 82 and Freesat channel 202.
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